Shop/5-Amino-1MQ 50mg
5-Amino-1MQ 50mg — research compound vial with batch and COA readout Third-Party COA Available
Small Molecule

5-Amino-1MQ 50mg

SKU: ADL-5A1MQ-50

Strength

50mg

Purity

99.398% Purity

$65.00

5-Amino-1MQ 50mg | Lyophilized Powder | RUO. Format: Lyophilized powder. Quantity: 50mg. Purity: Pending COA verification. Storage: -20°C, protect from moisture and light. Stability: 24 months lyophilized. For research use only. Not intended for human or veterinary use. Must be handled by qualified personnel in a proper research setting.

Third-Party COA AvailableEvery product displays verified third-party COA status.

Batch #

ADL-5AM-001

Purity

99.398%

Test Date

2026-07-11

Lab

Kovera Labs

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Specifications

CAS Number

2206728-48-3

Molecular Formula

C11H14N2O2

Molecular Weight

206.24 g/mol

Amino Acid Sequence

N/A

Nominal Content

50mg

Identity Result

Conforms to reference standard

Storage & Handling

Storage Conditions

-20°C, protect from moisture and light

Research Overview

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule compound, not a peptide, belonging to the quinolinium class of heterocyclic organic compounds. It is characterized by a methylated nitrogen within a bicyclic aromatic ring system with an amino substituent at the 5-position. Researchers study 5-Amino-1MQ primarily for its role as a potent, selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in the regulation of cellular NAD+ metabolism and one-carbon metabolic pathways. NNMT transfers a methyl group from S-adenosyl methionine (SAM) to nicotinamide, influencing methylation capacity and cellular energy homeostasis. Its high membrane permeability and selectivity for NNMT make it a valuable pharmacological tool compound for dissecting NNMT-dependent biochemical pathways in cell-culture and biochemical assay research settings. 5-Amino-1MQ is supplied as a lyophilized research material for laboratory in vitro and analytical use only.

References

  1. [1]
    Neelakantan H, Vance V, Wetzel MD, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology. 2018;147:141-152.
  2. [2]
    Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. Journal of Medicinal Chemistry. 2017;60(12):5015-5028.
  3. [3]
    Parsons RB, Ramsden DB. The expression of nicotinamide N-methyltransferase in the human central nervous system. Journal of Neuropathology & Experimental Neurology. 2016;75(6):590-597.
  4. [4]
    Hong S, Moreno-Navarrete JM, Wei X, et al. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nature Medicine. 2015;21(8):887-894.
  5. [5]
    Kannt A, Rajagopal S, Bhatt DL, et al. Inhibition of Nicotinamide N-Methyltransferase (NNMT) as a strategy for pharmacological modulation of NAD+ metabolism. Medicinal Research Reviews. 2021;41(3):1582-1603.

Resources & Verification

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Research Disclaimer

Important information about research-use-only status

Research Resources

Compound handling, storage, and terminology guide

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Research Use Only

All compounds and content on this site are for research use only (RUO). Not for human consumption. For laboratory and research purposes only. Nothing here is medical advice.