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MOTS-c 40mg Third-Party COA Available
Mitochondrial

MOTS-c 40mg

SKU: ADL-MTC-40

Strength

40mg

Purity

99.726% Purity

$86.00

MOTS-c 40mg | Lyophilized Powder | RUO. Format: Lyophilized powder. Quantity: 40mg. Purity: 99.726% (Third-Party Verified). Storage: -20°C, protect from moisture and light. Stability: 24 months lyophilized. For research use only. Not intended for human or veterinary use. Must be handled by qualified personnel in a proper research setting.

Third-Party COA AvailableEvery product displays verified third-party COA status.

Batch #

ADL-MTC-001

Purity

99.726%

Test Date

2026-07-12

Lab

Kovera Labs

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Specifications

CAS Number

1450155-55-1

Molecular Formula

C174H296N56O55S

Molecular Weight

4056.65 g/mol

Amino Acid Sequence

MRWQEMGYIFYPRKLR

Nominal Content

40mg

Identity Result

Conforms to reference standard

Storage & Handling

Storage Conditions

-20°C (frozen), protect from moisture and light

Research Overview

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino acid mitochondria-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome. Unlike nuclear-encoded peptides, MOTS-c is translated from a small open reading frame within mitochondrial DNA. Biochemically, MOTS-c has been shown in research models to translocate to the nucleus under metabolic stress conditions, where it interacts with the AMPK signaling pathway and modulates nuclear gene expression related to cellular metabolic homeostasis. Researchers study MOTS-c as a molecular tool to investigate metabolic signaling pathways, including glucose utilization, insulin signaling pathways, and mitochondrial function. Current areas of biochemical investigation include its interaction with folate cycle intermediates and its capacity to modulate reactive oxygen species (ROS) dynamics in cell-culture models. MOTS-c is supplied as a lyophilized research material for laboratory in vitro and analytical use only.

References

  1. [1]
    Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-454.
  2. [2]
    Kim SJ, Xiao J, Wan J, Cohen P, Yen K. Mitochondrially derived peptides as novel regulators of metabolism. J Physiol. 2017;595(21):6613-6621.
  3. [3]
    Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Bhatt DL, Yen K, Lee C. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021;12(1):470.
  4. [4]
    Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Commun Biol. 2016;19(1):1-12.
  5. [5]
    Lee C, Kim KH, Cohen P. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016;100:182-187.

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Resources & Verification

COA Registry

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FAQ

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Research Disclaimer

Important information about research-use-only status

Research Resources

Compound handling, storage, and terminology guide

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Research Use Only

All compounds and content on this site are for research use only (RUO). Not for human consumption. For laboratory and research purposes only. Nothing here is medical advice.