Thymosin Beta-4 (TB-4) — Full Length 43 AA, 5mg (TB-500 alias)

Research Overview

Full-length Thymosin Beta-4 (TB-4) is a naturally occurring 43-amino acid peptide originally isolated from thymic tissue, encoded by the TMSB4X gene in humans. Chemically, it belongs to the beta-thymosin family and is characterized by a conserved actin-sequestering domain (LKKTET motif) that enables high-affinity binding to G-actin monomers, thereby regulating actin polymerization dynamics within the cytoskeleton. Researchers study TB-4 primarily for its role in modulating actin homeostasis, cell migration, and cytoskeletal reorganization. Its biological activity is linked to the upregulation of metalloproteinases and the activation of the ILK (integrin-linked kinase) signaling pathway. As a research compound, TB-4 serves as a molecular tool to investigate actin dynamics and cell motility pathways in in vitro and in vivo experimental models. TB-4 is supplied as a lyophilized research material for laboratory in vitro and analytical use only.